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#NBME 19 ALLOSTERIC ACTIVATOR PROFESSIONAL#

Marvin and Hadassah Bacaner Research Awards

Center for the Art of Medicine Overview.

The Whiteside Institute for Clinical Research.

University of Minnesota Medical School Resources for Grief.

We are studying how the Src-family kinases, especially LynA, tune the sensitivity of macrophages and other immune cells to triggering and the regulation or dysregulation of these processes in autoimmune disease, infection, and breast cancer. Under normal circumstances small debris cannot trigger macrophage activation, but this regulatory process can be subverted in inflamed tissues. In macrophages Src-family tyrosine kinases (LynA, LynB, Hck, and Fgr) regulate a size sensing mechanism based on their ability to nucleate clustering of ITAM-coupled receptors. Immune cells are tuned exquisitely to identify pathogens and avoid hypersensitivity.

The American Association of Immunologists (AAI)Īmerican Association for Cancer Research (AACR) Research Research Summary/Interests

#NBME 19 ALLOSTERIC ACTIVATOR PROFESSIONAL#

Veneziale-Steer Award for Research in Cellular Growth Regulation (Predoctoral Student Ben Brian), UMN Medical School (2020) Professional Associations Jacob Kaplan Award in Clinical or Basic Medical Research (Predoctoral Student Ben Brian), UMN Medical School (2020) Shideman Research Proposal Award (Predoctoral Student Ben Brian), Department of Pharmacology (2019) Marvin and Hadassah Bacaner Research Award in Pharmacology (Predoctoral Student Ben Brian), UMN Medical School (2020)įrederick E. NIH T32 Training Award (Postdoctoral Fellow J.T. Howard Hughes Medical Institute REU Fellowship (1998) Outstanding Graduate Student Instructor Award, University of California, Berkeley (2004)Ĭopeland-Gross Biology Prize, Bowdoin College, Brunswick, ME (1999) NIH F32 NRSA Individual Postdoctoral Fellowship F32 AI082926 (2011) NIH T32 Training Award (Predoctoral Student Ben Brian) DA007097 (2016) Travel Award, FASEB Science Research Conferences (2017) Travel Award, FASEB Science Research Conferences (2018) NIH T32 Training Award (Predoctoral Student Monica Sauer) CA009138 (2021)Īmerican Cancer Society – Kirby Foundation Postdoctoral Fellowship (J.T. Protein tyrosine kinases, including Lyn and the other Src-family kinases, are modulators of cell sensitivity, and thus cell- and receptor-specific modes of kinase regulation and function are areas of special interest to her lab. Freedman's independent research program at UMN focuses on how myeloid cells integrate positive- and negative-regulatory signals to achieve tissue-specific functions and drive pathologies from autoimmune diseases to breast cancer. Arthur Weiss at UCSF, she discovered a mechanism by which the Src-family kinase LynA tunes macrophage sensitivity to pro-inflammatory activation, a process with implications for myeloid-cell hypersensitization in autoimmune disease. Freedman discovered structural and dynamic mechanisms underlying differential allosteric activation of the Ras-activating proteins Sos and RasGRF1. Working jointly in the laboratories of Drs. She received her AB degree with honors in Biochemistry from Bowdoin College (Brunswick, ME) before moving to UC Berkeley to enter the PhD program in Molecular and Cell Biology. She is also a member of the UMN Masonic Cancer Center's Immunology Program and the Center for Autoimmune Diseases Research. Freedman is an Assistant Professor of Pharmacology, housed in the Center for Immunology at University of Minnesota (UMN).